Ontology highlight
ABSTRACT:
SUBMITTER: Abaev I
PROVIDER: S-EPMC3730814 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Abaev Igor I Foster-Frey Juli J Korobova Olga O Shishkova Nina N Kiseleva Natalia N Kopylov Pavel P Pryamchuk Sergey S Schmelcher Mathias M Becker Stephen C SC Donovan David M DM
Applied microbiology and biotechnology 20120710 8
Staphylococcus aureus is a notorious pathogen highly successful at developing resistance to virtually all antibiotics to which it is exposed. Staphylococcal phage 2638A endolysin is a peptidoglycan hydrolase that is lytic for S. aureus when exposed externally, making it a new candidate antimicrobial. It shares a common protein organization with more than 40 other reported staphylococcal peptidoglycan hydrolases. There is an N-terminal M23 peptidase domain, a mid-protein amidase 2 domain (N-acety ...[more]