Ontology highlight
ABSTRACT:
SUBMITTER: Son B
PROVIDER: S-EPMC7843465 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Son Bokyung B Kong Minsuk M Lee Yoona Y Ryu Sangryeol S
Frontiers in microbiology 20210115
As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics. However, the discovery of potent endolysin is still challenging because it is labor intensive and difficult to obtain a soluble form with high lytic activity. In this respect, the modular structures of Gram-positive endolysins can provide an opportunity to develop novel endolysins by domain rearrangement. In this study, a random domain swappin ...[more]