Novel antibodies targeting immune regulatory checkpoints for cancer therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Lee CS
PROVIDER: S-EPMC3731598 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Novel antibodies targeting immune regulatory checkpoints for cancer therapy.
Lee Chern Siang CS Cragg Mark M Glennie Martin M Johnson Peter P
British journal of clinical pharmacology 20130801 2
Cancers must evade or suppress the immune system in order to develop. Better understanding of the molecular regulation governing tumour detection and effective activation of the immune system (so called immune regulatory checkpoints) has provided new targets for cancer immunotherapy. Therapeutic monoclonal antibodies against these targets are currently undergoing clinical evaluation with more in pre-clinical development; buoyed by the recent licence approval of the anti-CTLA-4 antibody, ipilumum ...[more]
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