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Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid Tumors.

ABSTRACT: Recently, modulation of immune checkpoints has risen to prominence as a means to treat a number of solid malignancies, given the durable response seen in many patients and improved side effect profile compared to conventional chemotherapeutic agents. Several classes of immune checkpoint modulators have been developed. Here, we review current monoclonal antibodies directed against immune checkpoints that are employed in practice today. We discuss the history, mechanism, indications, and clinical data for each class of therapies. Furthermore, we review the challenges to durable tumor responses that are seen in some patients and discuss possible interventions to circumvent these barriers.

SUBMITTER: Gravbrot N

PROVIDER: S-EPMC6963985 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid Tumors.

Gravbrot Nicholas N Gilbert-Gard Kacy K Mehta Paras P Ghotmi Yarah Y Banerjee Madhulika M Mazis Christopher C Sundararajan Srinath S

Antibodies (Basel, Switzerland) 20191021 4

Recently, modulation of immune checkpoints has risen to prominence as a means to treat a number of solid malignancies, given the durable response seen in many patients and improved side effect profile compared to conventional chemotherapeutic agents. Several classes of immune checkpoint modulators have been developed. Here, we review current monoclonal antibodies directed against immune checkpoints that are employed in practice today. We discuss the history, mechanism, indications, and clinical ...[more]

PMID: 31640266

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