Ontology highlight
ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC3731752 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Hu Xuebo X Saha Piyali P Chen Xiaoyue X Kim Dogeun D Devarasetty Mahesh M Varadarajan Raghavan R Jin Moonsoo M MM
Journal of the American Chemical Society 20120828 36
Helix-helix interactions are fundamental to many biological signals and systems and are found in homo- or heteromultimerization of signaling molecules as well as in the process of virus entry into the host. In HIV, virus-host membrane fusion during infection is mediated by the formation of six-helix bundles (6HBs) from homotrimers of gp41, from which a number of synthetic peptides have been derived as antagonists of virus entry. Using a yeast surface two-hybrid (YS2H) system, a platform designed ...[more]