Ontology highlight
ABSTRACT:
SUBMITTER: Danese E
PROVIDER: S-EPMC3731755 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20121107 6
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigating the impact of the CYP4F2 rs2108622 (p.V433M) polymorphism on coumarin dose requirement. An additional aim was to explore the contribution of the CYP4F2 variant in comparison with, as well as after stratification for, the VKORC1 and CYP2C9 variants. Thirty studies involving 9,470 participants met prespecified inclusion criteria. As compared with CC-homozygo ...[more]