Ontology highlight
ABSTRACT:
SUBMITTER: Grada Z
PROVIDER: S-EPMC3731887 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Grada Zakaria Z Hegde Meenakshi M Byrd Tiara T Shaffer Donald R DR Ghazi Alexia A Brawley Vita S VS Corder Amanda A Schönfeld Kurt K Koch Joachim J Dotti Gianpietro G Heslop Helen E HE Gottschalk Stephen S Wels Winfried S WS Baker Matthew L ML Ahmed Nabil N
Molecular therapy. Nucleic acids 20130709
Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through both distinct and redundant mechanisms. Hence, targeting multiple cancer-specific markers simultaneously could result in better therapeutic efficacy. We created a functional chimeric antigen receptor-the TanCAR, a novel artificial molecule that mediates bispecific activation and targeting of T cells. We demonstrate the feasibility of cumu ...[more]