Ontology highlight
ABSTRACT:
SUBMITTER: Woyach JA
PROVIDER: S-EPMC3731920 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Woyach Jennifer A JA Ruppert Amy S AS Rai Kanti K Lin Thomas S TS Geyer Susan S Kolitz Jonathan J Appelbaum Frederick R FR Tallman Martin S MS Belch Andrew R AR Morrison Vicki A VA Larson Richard A RA Byrd John C JC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20121210 4
<h4>Purpose</h4>Chronic lymphocytic leukemia (CLL) is a disease of the elderly, yet few clinical trials include a significant number of older patients, and outcomes after specific therapies can be different depending on age.<h4>Patients and methods</h4>We examined patients enrolled onto successive first-line CALGB CLL trials to determine whether efficacy of regimens varied by age, focusing on ideal chemotherapy choice and benefit of immunotherapy addition to chemotherapy in older patients. Regim ...[more]