Ontology highlight
ABSTRACT:
SUBMITTER: Otero K
PROVIDER: S-EPMC3732181 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Otero Karel K Shinohara Masahiro M Zhao Haibo H Cella Marina M Gilfillan Susan S Colucci Angela A Faccio Roberta R Ross F Patrick FP Teitelbaum Steve L SL Takayanagi Hiroshi H Colonna Marco M
Journal of immunology (Baltimore, Md. : 1950) 20120206 6
TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits intracellular signals through the adaptor DAP12. Individuals with genetic mutations inactivating TREM2 or DAP12 develop the Nasu-Hakola disease (NHD) with cystic-like lesions of the bone and brain demyelination that lead to fractures and presenile dementia. The mechanisms of this disease are poorly understood. In this study, we report that TREM2-deficient mice have an osteopenic phenotype reminiscent of NHD. In ...[more]