Ontology highlight
ABSTRACT:
SUBMITTER: Taylor EM
PROVIDER: S-EPMC37326 | biostudies-literature | 2001 Jun
REPOSITORIES: biostudies-literature
Taylor E M EM Moghraby J S JS Lees J H JH Smit B B Moens P B PB Lehmann A R AR
Molecular biology of the cell 20010601 6
The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an essential function in DNA replication and mitotic control. It has a heterodimeric partner SMC protein, Spr18, with which it forms the core of a multiprotein complex. We have now isolated the human orthologues of rad18 and spr18 and designated them hSMC6 and hSMC5. Both proteins are about 1100 amino acids in length and are 27-28% identical to their ...[more]