Ontology highlight
ABSTRACT:
SUBMITTER: Walker SR
PROVIDER: S-EPMC3732813 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Molecular and cellular endocrinology 20130324 1
The transcription factors STAT3 and STAT5 play important roles in the regulation of mammary gland function during pregnancy, lactation, and involution. Given that STAT3 and STAT5 regulate genes involved in proliferation and survival, it is not surprising that inappropriate activation of STAT3 and STAT5 occurs commonly in breast cancer. Although these proteins are structurally similar, they have divergent and opposing effects on gene expression and cellular phenotype. Notably, when STAT5 and STAT ...[more]