Ontology highlight
ABSTRACT:
SUBMITTER: Oliver AW
PROVIDER: S-EPMC373339 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Oliver Antony W AW Amé Jean-Christophe JC Roe S Mark SM Good Valerie V de Murcia Gilbert G Pearl Laurence H LH
Nucleic acids research 20040122 2
Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DN ...[more]