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O(2)-Protected Diazeniumdiolate-Modified Silica Nanoparticles for Extended Nitric Oxide Release from Dental Composites.

ABSTRACT: O(2)-protected N-diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 ?mol NO/mg and NO release half-life of 23 d. Reduced (3-log) Streptococcus mutans viable adhesion was observed for NO-releasing dental restorative materials modified with these particles relative to controls.

SUBMITTER: Carpenter AW

PROVIDER: S-EPMC3733399 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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O2-Protected Diazeniumdiolate-Modified Silica Nanoparticles for Extended Nitric Oxide Release from Dental Composites.

Carpenter Alexis W AW Reighard Katelyn P KP Saavedra Joseph E JE Schoenfisch Mark H MH

Biomaterials science 20130501 5

O2-protected N-diazeniumdiolate-based silanes were grafted onto mesoporous silica nanoparticles to yield a scaffold with an NO payload of 2.4 μmol NO/mg and NO release half-life of 23 d. Reduced (3-log) Streptococcus mutans viable adhesion was observed for NO-releasing dental restorative materials modified with these particles relative to controls. ...[more]

PMID: 23930221

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