Ontology highlight
ABSTRACT:
SUBMITTER: Fukuzaki E
PROVIDER: S-EPMC3733457 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Fukuzaki Emiko E Takuma Kazuhiro K Funatsu Yoko Y Himeno Yukiko Y Kitahara Yuko Y Gu Bin B Mizoguchi Hiroyuki H Ibi Daisuke D Koike Koji K Inoue Masaki M Yan Shi Du SD Yamada Kiyofumi K
Neurochemistry international 20080310 7
Ovarian hormone decline after menopause may influence cognitive performance and increase the risk for Alzheimer's disease (AD) in women. Amyloid-beta peptide (Abeta) has been proposed to be the primary cause of AD. In this study, we examined whether ovariectomy (OVX) could affect the levels of cofactors Abeta-binding alcohol dehydrogenase (ABAD) and receptor for advanced glycation endproducts (RAGE), which have been reported to potentiate Abeta-mediated neuronal perturbation, in mouse hippocampu ...[more]