Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC6971075 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Chen Gefei G Andrade-Talavera Yuniesky Y Tambaro Simone S Leppert Axel A Nilsson Harriet E HE Zhong Xueying X Landreh Michael M Nilsson Per P Hebert Hans H Biverstål Henrik H Fisahn André A Abelein Axel A Johansson Jan J
Communications biology 20200120 1
Molecular chaperones play important roles in preventing protein misfolding and its potentially harmful consequences. Deterioration of molecular chaperone systems upon ageing are thought to underlie age-related neurodegenerative diseases, and augmenting their activities could have therapeutic potential. The dementia relevant domain BRICHOS from the Bri2 protein shows qualitatively different chaperone activities depending on quaternary structure, and assembly of monomers into high-molecular weight ...[more]