Ontology highlight
ABSTRACT:
SUBMITTER: Hood FE
PROVIDER: S-EPMC3734082 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Hood Fiona E FE Williams Samantha J SJ Burgess Selena G SG Richards Mark W MW Roth Daniel D Straube Anne A Pfuhl Mark M Bayliss Richard R Royle Stephen J SJ
The Journal of cell biology 20130801 3
A complex of transforming acidic coiled-coil protein 3 (TACC3), colonic and hepatic tumor overexpressed gene (ch-TOG), and clathrin has been implicated in mitotic spindle assembly and in the stabilization of kinetochore fibers by cross-linking microtubules. It is unclear how this complex binds microtubules and how the proteins in the complex interact with one another. TACC3 and clathrin have each been proposed to be the spindle recruitment factor. We have mapped the interactions within the compl ...[more]