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Quantum chemistry as a tool in asymmetric biocatalysis: limonene epoxide hydrolase test case.

ABSTRACT: Cluster model: Large active-site models (see figure) are used to investigate the selectivity of limonene epoxide hydrolase, both the wild type and mutants optimized through directed evolution. Good agreement is found between theory and the experimental data, thus demonstrating that the quantum chemical cluster approach can be a powerful tool in the field of asymmetric biocatalysis.

SUBMITTER: Lind ME

PROVIDER: S-EPMC3734700 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Quantum chemistry as a tool in asymmetric biocatalysis: limonene epoxide hydrolase test case.

Lind Maria E S ME Himo Fahmi F

Angewandte Chemie (International ed. in English) 20130319 17

Cluster model: Large active-site models (see figure) are used to investigate the selectivity of limonene epoxide hydrolase, both the wild type and mutants optimized through directed evolution. Good agreement is found between theory and the experimental data, thus demonstrating that the quantum chemical cluster approach can be a powerful tool in the field of asymmetric biocatalysis. ...[more]

PMID: 23512539

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