Ontology highlight
ABSTRACT:
SUBMITTER: Ayuso MI
PROVIDER: S-EPMC3734765 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Ayuso María Irene MI Martínez-Alonso Emma E Cid Cristina C Alonso de Leciñana Maria M Alcázar Alberto A
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20130417 8
Transient brain ischemia induces an inhibition of translational rates and causes delayed neuronal death in selective regions and cognitive deficits, whereas these effects do not occur in resistant areas. The translational repressor eukaryotic initiation factor (eIF) 4E-binding protein-2 (4E-BP2) specifically binds to eIF4E and is critical in the control of protein synthesis. To link neuronal death to translation inhibition, we study the eIF4E association with 4E-BP2 under ischemia reperfusion in ...[more]