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Resistance of optogenetically evoked motor function to global ischemia and reperfusion in mouse in vivo.

ABSTRACT: Recently we have shown that despite reperfusion, sensory processing exhibits persistent deficits after global ischemia in a mouse in vivo model. We now address how motor output, specifically cortically evoked muscle activity, stimulated by channelrhodopsin-2 is affected by global ischemia and reperfusion. We find that the light-based optogenetic motor map recovers to 80% within an hour. Moreover, motor output recovers relatively faster and more completely than the sensory processing after 5-minute period of global ischemia. Our results suggest a differential sensitivity of sensory and motor systems to the effects of global ischemia and reperfusion that may have implications for rehabilitation.

SUBMITTER: Xie Y

PROVIDER: S-EPMC3734785 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Resistance of optogenetically evoked motor function to global ischemia and reperfusion in mouse in vivo.

Xie Yicheng Y Chen Shangbin S Anenberg Eitan E Murphy Timothy H TH

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20130605 8

Recently we have shown that despite reperfusion, sensory processing exhibits persistent deficits after global ischemia in a mouse in vivo model. We now address how motor output, specifically cortically evoked muscle activity, stimulated by channelrhodopsin-2 is affected by global ischemia and reperfusion. We find that the light-based optogenetic motor map recovers to 80% within an hour. Moreover, motor output recovers relatively faster and more completely than the sensory processing after 5-minu ...[more]

PMID: 23736644

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