Ontology highlight
ABSTRACT:
SUBMITTER: Gaud G
PROVIDER: S-EPMC3734840 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gaud G G Guillemot D D Jacob Y Y Favre M M Vuillier F F
Cell death & disease 20130221
EVER1 and 2 confer resistance to cutaneous oncogenic human papillomavirus infections by downregulating the activating protein 1 (AP-1) signaling pathway. Defects in their expression are associated with susceptibility to epidermodysplasia verruciformis, which is characterized by persistent β-HPV infection, tumor necrosis factor alpha (TNF-α) overproduction in keratinocytes and the development of skin cancers. TNF-α-induced apoptosis is a key defense strategy, preventing the persistence of the vir ...[more]