Ontology highlight
ABSTRACT:
SUBMITTER: Huang HL
PROVIDER: S-EPMC3735459 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Huang Hong-Ling HL Wang Shimin S Yin Meng-Xin MX Dong Liang L Wang Chao C Wu Wei W Lu Yi Y Feng Miao M Dai Chuanyang C Guo Xiaocan X Li Li L Zhao Bin B Zhou Zhaocai Z Ji Hongbin H Jiang Jin J Zhao Yun Y Liu Xin-Yuan XY Zhang Lei L
PLoS biology 20130806 8
The evolutionarily conserved Hippo (Hpo) signaling pathway plays a pivotal role in organ size control by balancing cell proliferation and cell death. Here, we reported the identification of Par-1 as a regulator of the Hpo signaling pathway using a gain-of-function EP screen in Drosophila melanogaster. Overexpression of Par-1 elevated Yorkie activity, resulting in increased Hpo target gene expression and tissue overgrowth, while loss of Par-1 diminished Hpo target gene expression and reduced orga ...[more]