Ontology highlight
ABSTRACT:
SUBMITTER: Seo E
PROVIDER: S-EPMC4994041 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Seo Eunjeong E Kim Wan-Young WY Hur Jeongmi J Kim Hanbyul H Nam Sun Ah SA Choi Arum A Kim Yu-Mi YM Park Sang Hee SH Chung Chaeuk C Kim Jin J Min Soohong S Myung Seung-Jae SJ Lim Dae-Sik DS Kim Yong Kyun YK
Scientific reports 20160823
Renal tubulointerstitial fibrosis (TIF) is the final pathway of various renal injuries that result in chronic kidney disease. The mammalian Hippo-Salvador signaling pathway has been implicated in the regulation of cell proliferation, cell death, tissue regeneration, and tumorigenesis. Here, we report that the Hippo-Salvador pathway plays a role in disease development in patients with TIF and in a mouse model of TIF. Mice with tubular epithelial cell (TEC)-specific deletions of Sav1 (Salvador hom ...[more]