Ontology highlight
ABSTRACT:
SUBMITTER: Brown CR
PROVIDER: S-EPMC3735467 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Brown Christopher R CR Mao Changhui C Falkovskaia Elena E Jurica Melissa S MS Boeger Hinrich H
PLoS biology 20130806 8
The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, causing transcription to occur in bursts. However, the molecular basis of transcriptional bursting remains poorly understood. By electron microscopy of single PHO5 gene molecules from yeast, we show that the "activated" promoter assumes alternative nucle ...[more]