Stochastic fluctuations and distributed control of gene expression impact cellular memory.
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ABSTRACT:
SUBMITTER: Corre G
PROVIDER: S-EPMC4274012 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Stochastic fluctuations and distributed control of gene expression impact cellular memory.
Corre Guillaume G Stockholm Daniel D Arnaud Ophélie O Kaneko Gaël G Viñuelas José J Yamagata Yoshiaki Y Neildez-Nguyen Thi My Anh TM Kupiec Jean-Jacques JJ Beslon Guillaume G Gandrillon Olivier O Paldi András A
PloS one 20141222 12
Despite the stochastic noise that characterizes all cellular processes the cells are able to maintain and transmit to their daughter cells the stable level of gene expression. In order to better understand this phenomenon, we investigated the temporal dynamics of gene expression variation using a double reporter gene model. We compared cell clones with transgenes coding for highly stable mRNA and fluorescent proteins with clones expressing destabilized mRNA-s and proteins. Both types of clones d ...[more]
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