Ontology highlight
ABSTRACT:
SUBMITTER: Li ZF
PROVIDER: S-EPMC3735495 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Li Zhou Fang ZF Liang Yi Min YM Lau Pui Ngan PN Shen Wei W Wang Dai Kui DK Cheung Wing Tai WT Xue Chun Jason CJ Poon Lit Man LM Lam Yun Wah YW
PloS one 20130806 8
Although microRNAs are commonly known to function as a component of RNA-induced silencing complexes in the cytoplasm, they have been detected in other organelles, notably the nucleus and the nucleolus, of mammalian cells. We have conducted a systematic search for miRNAs in HeLa cell nucleoli, and identified 11 abundant miRNAs with a high level of nucleolar accumulation. Through in situ hybridisation, we have localised these miRNAs, including miR-191 and miR-484, in the nucleolus of a diversity o ...[more]