Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe A
PROVIDER: S-EPMC3736980 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Watanabe Akira A Choe Seungho S Chaptal Vincent V Rosenberg John M JM Wright Ernest M EM Grabe Michael M Abramson Jeff J
Nature 20101205 7326
Membrane co-transport proteins that use a five-helix inverted repeat motif have recently emerged as one of the largest structural classes of secondary active transporters. However, despite many structural advances there is no clear evidence of how ion and substrate transport are coupled. Here we report a comprehensive study of the sodium/galactose transporter from Vibrio parahaemolyticus (vSGLT), consisting of molecular dynamics simulations, biochemical characterization and a new crystal structu ...[more]