Ontology highlight
ABSTRACT:
SUBMITTER: Schulte JD
PROVIDER: S-EPMC3737231 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Schulte Jessica D JD Srikanth Maya M Das Sunit S Zhang Jianing J Lathia Justin D JD Yin Lihui L Rich Jeremy N JN Olson Eric C EC Kessler John A JA Chenn Anjen A
PloS one 20130807 8
Metastasizing tumor cells undergo a transformation that resembles a process in normal development when non-migratory epithelial cells modulate the expression of cytoskeletal and adhesion proteins to promote cell motility. Here we find a mesenchymal cadherin, Cadherin-11 (CDH11), is increased in cells exiting the ventricular zone (VZ) neuroepithelium during normal cerebral cortical development. When overexpressed in cortical progenitors in vivo, CDH11 causes premature exit from the neuroepitheliu ...[more]