Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC2865854 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Zhang Jianing J Woodhead Gregory J GJ Swaminathan Sruthi K SK Noles Stephanie R SR McQuinn Erin R ER Pisarek Anna J AJ Stocker Adam M AM Mutch Christopher A CA Funatsu Nobuo N Chenn Anjen A
Developmental cell 20100301 3
Little is known about the architecture of cellular microenvironments that support stem and precursor cells during tissue development. Although adult stem cell niches are organized by specialized supporting cells, in the developing cerebral cortex, neural stem/precursor cells reside in a neurogenic niche lacking distinct supporting cells. Here, we find that neural precursors themselves comprise the niche and regulate their own development. Precursor-precursor contact regulates beta-catenin signal ...[more]