Ontology highlight
ABSTRACT:
SUBMITTER: Richter H
PROVIDER: S-EPMC3737328 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Richter Hagen H Lange Sita J SJ Backofen Rolf R Randau Lennart L
RNA biology 20130501 5
The prokaryotic antiviral defense systems CRISP R (clustered regularly interspaced short palindromic repeats)/Cas (CRISP Rassociated) employs short crRNAs (CRISP R RNAs) to target invading viral nucleic acids. A short spacer sequence of these crRNAs can be derived from a viral genome and recognizes a reoccurring attack of a virus via base complementarity. We analyzed the effect of spacer sequences on the maturation of crRNAs of the subtype I-B Methanococcus maripaludis C5 CRISP R cluster. The re ...[more]