Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4286480 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20141126 1
The Cas6 superfamily, the Cas5d subclass, and the host RNase III endoribonucleases are responsible for producing small RNAs (crRNA) that function in the CRISPR-Cas immunity. The three enzymes may also interact with the crRNA-associated nucleic acid interference complexes. Recent development in structural biology of Cas6 and Cas5d and their complexes with RNA substrates has lent new insights on principles of crRNA processing and the structural basis for linking crRNA processing to interference. B ...[more]