Ontology highlight
ABSTRACT:
SUBMITTER: Maslennikov I
PROVIDER: S-EPMC3737378 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Maslennikov Innokentiy I Choe Senyon S
Current opinion in structural biology 20130527 4
Integral membrane proteins (IMPs) play a central role in cell communication with the environment. Their structures are essential for our understanding of the molecular mechanisms of signaling and for drug design, yet they remain badly underrepresented in the protein structure databank. Solution NMR is, aside from X-ray crystallography, the major tool in structural biology. Here we review recently reported solution NMR structures of polytopic IMPs and discuss the new approaches, which were develo ...[more]