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Modulation of the current signatures of DNA abasic site adducts in the ?-hemolysin ion channel.


ABSTRACT: Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound ?-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA-protein interactions and the size limitation of bulky adducts to be translocated.

SUBMITTER: An N 

PROVIDER: S-EPMC3738171 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel.

An Na N   White Henry S HS   Burrows Cynthia J CJ  

Chemical communications (Cambridge, England) 20121017 93


Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound α-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA-protein interactions and the size limitation of bulky adducts to be translocated. ...[more]

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