Ontology highlight
ABSTRACT:
SUBMITTER: Wu W
PROVIDER: S-EPMC3739703 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Wu Wenjing W Bhagat Tushar D TD Yang Xue X Song Jee Hoon JH Cheng Yulan Y Agarwal Rachana R Abraham John M JM Ibrahim Sariat S Bartenstein Matthias M Hussain Zulfiqar Z Suzuki Masako M Yu Yiting Y Chen Wei W Eng Charis C Greally John J Verma Amit A Meltzer Stephen J SJ
Gastroenterology 20130116 5
<h4>Background & aims</h4>Alterations in methylation of protein-coding genes are associated with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Dysregulation of noncoding RNAs occurs during carcinogenesis but has never been studied in BE or EAC. We applied high-resolution methylome analysis to identify changes at genomic regions that encode noncoding RNAs in BE and EAC.<h4>Methods</h4>We analyzed methylation of 1.8 million CpG sites using massively parallel sequencing-based HELP t ...[more]