Ontology highlight
ABSTRACT:
SUBMITTER: Scotto M
PROVIDER: S-EPMC3740540 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Scotto M M Afonso G G Larger E E Raverdy C C Lemonnier F A FA Carel J C JC Dubois-Laforgue D D Baz B B Levy D D Gautier J F JF Launay O O Bruno G G Boitard C C Sechi L A LA Hutton J C JC Davidson H W HW Mallone R R
Diabetologia 20120420 7
<h4>Aims/hypothesis</h4>Anti-zinc transporter (ZnT)8 autoantibodies are commonly detected in type 1 diabetic patients. We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets.<h4>Methods</h4>Candidate epitopes were selected by ZnT8 plasmid DNA immunisation of HLA-A2/DQ8 transgenic mice and tested for T cell recognition in peripheral blood mononuclear cells of type 1 diabetic, type 2 diabetic and healthy participants by IFN- ...[more]