Ontology highlight
ABSTRACT:
SUBMITTER: Youngsaye W
PROVIDER: S-EPMC3740683 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Youngsaye Willmen W Hartland Cathy L CL Morgan Barbara J BJ Ting Amal A Nag Partha P PP Vincent Benjamin B Mosher Carrie A CA Bittker Joshua A JA Dandapani Sivaraman S Palmer Michelle M Whitesell Luke L Lindquist Susan S Schreiber Stuart L SL Munoz Benito B
Beilstein journal of organic chemistry 20130726
The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-ac ...[more]