Ontology highlight
ABSTRACT:
SUBMITTER: Banappagari S
PROVIDER: S-EPMC3740721 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20130428
Among the EGFRs, HER2 is a major heterodimer partner and also has important implications in the formation of particular tumors. Interaction of HER2 protein with other EGFR proteins can be modulated by small molecule ligands and, hence, these protein-protein interactions play a key role in biochemical reactions related to control of cell growth. A peptidomimetic (compound 5-1) that binds to HER2 protein extracellular domain and inhibits protein-protein interactions of EGFRs was conjugated with BO ...[more]