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Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin.

ABSTRACT: Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1-3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC50 = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM).

SUBMITTER: Lavoie S

PROVIDER: S-EPMC3740800 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin.

Lavoie Serge S Gauthier Charles C Legault Jean J Mercier Sylvain S Mshvildadze Vakhtang V Pichette André A

Beilstein journal of organic chemistry 20130704

Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1-3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus ...[more]

PMID: 23946828

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