Ontology highlight
ABSTRACT:
SUBMITTER: Barkauskaite E
PROVIDER: S-EPMC3741636 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity generates PAR fragments. Here we present the crystal structure of PARG incorporating the PAR substrate. The two terminal ADP-ribose units of the polymeric substrate are bound in exo-mode. Biochemical and modelling studies reveal that PARG acts pre ...[more]