Counting motifs in the human interactome.
Ontology highlight
ABSTRACT:
SUBMITTER: Tran NH
PROVIDER: S-EPMC3741638 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Counting motifs in the human interactome.
Tran Ngoc Hieu NH Choi Kwok Pui KP Zhang Louxin L
Nature communications 20130101
Small over-represented motifs in biological networks often form essential functional units of biological processes. A natural question is to gauge whether a motif occurs abundantly or rarely in a biological network. Here we develop an accurate method to estimate the occurrences of a motif in the entire network from noisy and incomplete data, and apply it to eukaryotic interactomes and cell-specific transcription factor regulatory networks. The number of triangles in the human interactome is abou ...[more]
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