Ontology highlight
ABSTRACT:
SUBMITTER: Kochi T
PROVIDER: S-EPMC3742268 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Kochi Takahiro T Shimizu Masahito M Ohno Tomohiko T Baba Atsushi A Sumi Takafumi T Kubota Masaya M Shirakami Yohei Y Tsurumi Hisashi H Tanaka Takuji T Moriwaki Hisataka H
International journal of molecular sciences 20130715 7
Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly intraperitoneal injections of AOM (20 m ...[more]