Modulation of oxidative stress by twist oncoproteins.
Ontology highlight
ABSTRACT:
SUBMITTER: Floc'h N
PROVIDER: S-EPMC3742535 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Modulation of oxidative stress by twist oncoproteins.
Floc'h Nicolas N Kolodziejski Jakub J Akkari Leila L Simonin Yannick Y Ansieau Stéphane S Puisieux Alain A Hibner Urszula U Lassus Patrice P
PloS one 20130813 8
Expression of developmental genes Twist1 and Twist2 is reactivated in many human tumors. Among their oncogenic activities, induction of epithelial to mesenchymal transition is believed to increase cell motility and invasiveness and may be related to acquisition of cancer stem cell phenotype. In addition, Twist proteins promote malignant conversion by overriding two oncogene-induced failsafe programs: senescence and apoptosis. Reactive oxygen species (ROS) are also important mediators of apoptosi ...[more]
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