Ontology highlight
ABSTRACT:
SUBMITTER: Lozano-Sepulveda SA
PROVIDER: S-EPMC4678374 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Lozano-Sepulveda Sonia A SA Bryan-Marrugo Owen L OL Cordova-Fletes Carlos C Gutierrez-Ruiz Maria C MC Rivas-Estilla Ana M AM
World journal of hepatology 20151201 29
Hepatitis C virus (HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system (GSH) and thioredo ...[more]