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The effect of polyhydroxylated alkaloids on maltase-glucoamylase.

ABSTRACT: One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes.

SUBMITTER: Shang Q

PROVIDER: S-EPMC3742645 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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The effect of polyhydroxylated alkaloids on maltase-glucoamylase.

Shang Qian Q Xiang Junfeng J Zhang Hong H Li Qian Q Tang Yalin Y

PloS one 20130813 8

One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and ...[more]

PMID: 23967118

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Structural insight into substrate specificity of human intestinal maltase-glucoamylase.

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Isolation of a detergent-solubilized maltase/glucoamylase from rat intestine and its comparison with a maltase/glucoamylase solubilized by papain.

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Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.

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Targeting N-Terminal Human Maltase-Glucoamylase to Unravel Possible Inhibitors Using Molecular Docking, Molecular Dynamics Simulations, and Adaptive Steered Molecular Dynamics Simulations.

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Studies on the size and shape of rabbit intestinal glucoamylase-maltase complex.

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