Ontology highlight
ABSTRACT:
SUBMITTER: Sugimoto N
PROVIDER: S-EPMC3743064 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sugimoto Naotoshi N Matsuzaki Kentaro K Ishibashi Hiroaki H Tanaka Masao M Sawaki Toshioki T Fujita Yoshimasa Y Kawanami Takafumi T Masaki Yasufumi Y Okazaki Toshiro T Sekine Joji J Koizumi Shoichi S Yachie Akihiro A Umehara Hisanori H Shido Osamu O
Scientific reports 20130101
It is known that aquaporin (AQP) 5 expression in the apical membrane of acinar cells in salivary glands is important for the secretion of saliva in rodents and humans. Although heat acclimation enhances saliva secretion in rodents, the molecular mechanism of how heat induces saliva secretion has not been determined. Here, we found that heat acclimation enhanced the expression of AQP5 and AQP1 in rat submandibular glands concomitant with the promotion of the HIF-1α pathway, leading to VEGF induct ...[more]