Ontology highlight
ABSTRACT:
SUBMITTER: Fiskus W
PROVIDER: S-EPMC3743080 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Fiskus Warren W Verstovsek Srdan S Manshouri Taghi T Rao Rekha R Balusu Ramesh R Venkannagari Sreedhar S Rao Nalabothula Narasimha NN Ha Kyungsoo K Smith Jacqueline E JE Hembruff Stacey L SL Abhyankar Sunil S McGuirk Joseph J Bhalla Kapil N KN
Clinical cancer research : an official journal of the American Association for Cancer Research 20111005 23
<h4>Purpose</h4>We determined the activity of hsp90 inhibitor, and/or Janus-activated kinase 2 (JAK2) tyrosine kinase inhibitor (TKI), against JAK2-V617F-expressing cultured mouse (Ba/F3-JAK2-V617F) and human (HEL92.1.7 and UKE-1) or primary human CD34(+) myeloproliferative neoplasm (MPN) cells.<h4>Experimental design</h4>Following exposure to the hsp90 inhibitor AUY922 and/or JAK2-TKI TG101209, the levels of JAK2-V617F, its downstream signaling proteins, as well as apoptosis were determined.<h4 ...[more]