Ontology highlight
ABSTRACT:
SUBMITTER: Lapaquette P
PROVIDER: S-EPMC3743084 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Lapaquette Pierre P Glasser Anne-Lise AL Huett Alan A Xavier Ramnik J RJ Darfeuille-Michaud Arlette A
Cellular microbiology 20090911 1
Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate within intestinal epithelial cells. Recent genome-wide association studies have highlighted the autophagy pathway as being associated with CD risk. In the present study we investigated whether defects in autophagy enhance replication of commensal and pathogenic Escherichia coli and CD-associated AIEC. We show that functional autophagy limits intrace ...[more]