Ontology highlight
ABSTRACT:
SUBMITTER: Kalaitzidis D
PROVIDER: S-EPMC3743253 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cell stem cell 20120901 3
The mechanistic target of rapamycin (mTOR) pathway serves as a key sensor of cellular-energetic state and functions to maintain tissue homeostasis. Hyperactivation of the mTOR pathway impairs hematopoietic stem cell (HSC) function and is associated with leukemogenesis. However, the roles of the unique mTOR complexes (mTORCs) in hematopoiesis and leukemogenesis have not been adequately elucidated. We deleted the mTORC1 component, regulatory-associated protein of mTOR (Raptor), in mouse HSCs and i ...[more]