Ontology highlight
ABSTRACT:
SUBMITTER: Guertin DA
PROVIDER: S-EPMC2701381 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20090201 2
mTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this function of mTORC2 is critical for cancer progression is unknown. Here, we show that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice. Furthermore, we find that Rictor is a haploinsufficient gene and that deleting one copy protects Pten heterozygous mice from prostate cancer. Fina ...[more]