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Enantioselective synthesis of the 5-6-7 carbocyclic core of the gagunin diterpenoids.

ABSTRACT: A catalytic enantioselective double allylic alkylation reaction has been employed in the synthesis of the core of the gagunin diterpenoids. Enantioenriched material was advanced in 11 steps to afford the core of the highly oxygenated target, which includes two all-carbon quaternary stereocenters.

SUBMITTER: Shibuya GM

PROVIDER: S-EPMC3743267 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Enantioselective synthesis of the 5-6-7 carbocyclic core of the gagunin diterpenoids.

Shibuya Grant M GM Enquist John A JA Stoltz Brian M BM

Organic letters 20130626 13

A catalytic enantioselective double allylic alkylation reaction has been employed in the synthesis of the core of the gagunin diterpenoids. Enantioenriched material was advanced in 11 steps to afford the core of the highly oxygenated target, which includes two all-carbon quaternary stereocenters. ...[more]

PMID: 23802176

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