Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC3744028 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chen Guang G Chen Xing X Sukumar Aravin A Gao Bo B Curley Jessica J Schnaper H William HW Ingram Alistair J AJ Krepinsky Joan C JC
Journal of cell science 20130618 Pt 16
Increased intraglomerular pressure is an important pathogenic determinant of kidney fibrosis in the progression of chronic kidney disease, and can be modeled by exposing glomerular mesangial cells (MC) to mechanical stretch. MC produce extracellular matrix and profibrotic cytokines, including connective tissue growth factor (CTGF) when stretched. We show that p21-activated kinase 1 (Pak1) is activated by stretch in MC in culture and in vivo in a process marked by elevated intraglomerular pressur ...[more]